First, I find the notion that there's some huge physical gap across the board largely unsupported. You'd think there are 400+ lb guys on both sides of the line across the board in the NFL. The transitions from college -> NFL have become a lot more seamless in the last decade, if you haven't noticed, with players being able to compete at almost every position in year 1. But we've conceded that, across the board, there's more "talent" in the NFL. So what? That's not insurmountable, particularly by a team with a great coach, a good amount of NFL talent themselves, pride, scheme and style. Would the best college team beat the worst NFL more often than not? God no. Could they beat them? You bet.